Evamist^® Resources

Do not start using Evamist^® (estradiol transdermal spray) if you:¹

• Have unusual vaginal bleeding
  • Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
• Currently have or have had certain cancers
  • Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use Evamist® (estradiol transdermal spray).
• Had a stroke or heart attack
• Currently have or have had blood clots
• Currently have or have had liver problems
• Have been diagnosed with a bleeding disorder
• Are allergic to Evamist^® or any of its ingredients
• Think you may be pregnant
  • Evamist® (estradiol transdermal spray) is not for pregnant women. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not use Evamist^® if the test is positive and talk to your healthcare provider.

Before you use Evamist^® (estradiol transdermal spray), tell your healthcare provider if you:

• Have any unusual vaginal bleeding
  • Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any vaginal bleeding to find out the cause.
• Have any other medical conditions
  • Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
• Are going to have surgery or will be on bed rest
  • Your healthcare provider will let you know if you need to stop using Evamist® (estradiol transdermal spray).
• Are breast feeding
  • The hormone in Evamist^® (estradiol transdermal spray) can pass into your breast milk.

Tell your healthcare provider about all the medicine you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Evamist^® (estradiol transdermal spray) works. Evamist^® may also affect how your other medicines work. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.¹

• Do not allow others to make contact with the area of skin where you applied Evamist® (estradiol transdermal spray)¹
• Because Evamist contains alcohol, which is flammable, avoid fire, flame, or smoking until the area of your skin where you have applied Evamist has dried¹

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:¹

• heart attack
• stroke
• blood clots
• dementia
• breast cancer
• cancer of the lining of the uterus (womb)
• cancer of the ovary
• high blood pressure
• high blood sugar
• gallbladder disease
• liver problems
• changes in your thyroid hormone levels
• enlargement of benign tumors of the uterus (“fibroids”)

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:¹

• new breast lumps
• unusual vaginal bleeding
• changes in vision or speech
• sudden new severe headaches
• severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue

Less serious, but common side effects include:¹

• headache
• breast pain
• irregular vaginal bleeding or spotting
• stomach or abdominal cramps, bloating
• nausea and vomiting
• hair loss
• fluid retention
• vaginal yeast infection

These are not all the possible side effects of Evamist® (estradiol transdermal spray). For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effect that bothers you or does not go away. You may report side effects to Perrigo at 1-866-634-9120 or to FDA at 1-800-FDA-1088.¹

Talk with your healthcare provider regularly about whether you should continue using Evamist® (estradiol transdermal spray).¹

• If you have a uterus, talk with your healthcare provider about whether the addition of a progestin is right for you.
• The addition of a progestin is generally recommended for women with a uterus to reduce the chance of getting cancer of the uterus.
• See your healthcare provider right away if you get vaginal bleeding while using Evamist® (estradiol transdermal spray).
• Have a pelvic exam, breast exam, and mammogram (breast X-ray) every year unless your healthcare provider tells you something else.
• If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast exams more often.
• If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or if you use tobacco, you may have a higher chance of getting heart disease.
• Ask your healthcare provider for ways to lower your chances of getting heart disease.

Store Evamist® (estradiol transdermal spray) at room temperature of 68°F to 77°F (20°C to 25°C). Do not freeze. Safely throw away medicine that is out of date or no longer needed.¹

Do not use Evamist® (estradiol transdermal spray) for conditions for which it was not prescribed. Do not give Evamist to other people, even if they have the same symptoms you have. It may harm them.¹