Evamist® (estradiol transdermal spray) is a prescription estrogen therapy indicated for the treatment of moderate to severe vasomotor symptoms — commonly known as hot flashes — due to menopause.¹
What is Evamist®?
Proven to reduce moderate-to-severe hot flashes caused by menopause.
Evamist® (estradiol transdermal spray) is a prescription medicine spray that has been shown to reduce both the severity and frequency of hot flashes.¹
Evamist® contains 17β-estradiol, an estrogen hormone chemically synthesized from a plant source.¹ It is the only estrogen therapy spray approved by the FDA.²
Download our patient brochure to learn more about Evamist® and how it’s applied.
What Makes Evamist® Different?
Evamist® is a once-daily transdermal spray for moderate to severe hot flashes due to menopause with a convenient once-daily application that dries within minutes, and individualized dosing (1-3 sprays as prescribed).
Hot Flash Relief
Precise Transdermal Mist
Once Daily Application
Estrogens with or without progestins should be used with the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
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How Evamist® Works
Evamist® delivers estradiol, an estrogen hormone, directly through the skin and into the bloodstream via a metered-dose spray applied once daily to the forearm. Because it’s absorbed transdermally rather than swallowed, it bypasses the digestive process associated with oral tablets.³
Dosing built around you
Each spray releases a consistent, measured dose of 1.53 mg of estradiol.¹ Treatment starts at one spray per day, and your healthcare provider can adjust you up to two or three sprays based on your response — without needing a new prescription for a different strength. You and your healthcare provider should talk regularly, for example every 3 to 6 months, about your dose and whether you still need treatment.
Backed by clinical evidence
In a 12-week, randomized, placebo-controlled clinical trial of 454 postmenopausal women, one, two, and three daily sprays of Evamist® each showed a statistically significant reduction in both the frequency and severity of moderate to severe hot flashes compared to placebo, with effects apparent by Week 4 and continuing through Week 12.1,4
How to Use Evamist®
Each Evamist® (estradiol transdermal spray) applicator contains enough medication to allow for initial priming of the pump with 5 sprays and application of 56 sprays, providing the precise amount of medicine each time the applicator is used.
The product will last approximately 56 days if you use 1 spray each day, 28 days if you use 2 sprays each day, and 18 days if you use 3 sprays each day. Do not use this applicator for more than 56 sprays even though the bottle may not be completely empty.
Tips for applying Evamist®:
- Before using the Evamist® (estradiol transdermal spray) applicator for the first time, it must be primed.
- With the cover on and the applicator upright, fully depress the applicator 5 times with your thumb or index finger.
- After priming, the applicator is ready to use.
- DO NOT PRIME THE APPLICATOR BEFORE EACH DAY’S DOSE.
- Do not apply Evamist® (estradiol transdermal spray) to other areas of the skin.
- Never apply Evamist directly to the breast or in or around the vagina.
Steps to avoid unintended estrogen exposure1
After you spray Evamist® (estradiol transdermal spray) on your skin, do not allow other people and pets to make contact with the area of skin where you applied the spray after application. Cover your skin with clothing where you sprayed Evamist® if you think another person will come in contact with that area of skin. If you get Evamist® spray on another area of your skin like your hands, wash that area of your skin with soap and water right away.
The estrogen in Evamist® (estradiol transdermal spray) can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed Evamist®. Young children who are accidentally exposed to estrogen through contact with women using Evamist® may show signs of puberty that are not expected (for example, breast budding).
If another person accidentally touches the area of your skin where you sprayed Evamist® (estradiol transdermal spray), tell that person to wash the area of their skin with soap and water right away. The longer Evamist® stays on the skin before it is washed off, the greater the chance the estrogen hormone may be absorbed.
If a child under your care unexpectedly starts to develop breasts or has other sexual changes:
- Have the child checked right away by their healthcare provider
- Stop using Evamist® (estradiol transdermal spray) and call your healthcare provider right away if you see any signs and symptoms in a child that may have occurred through accidental exposure to Evamist®. In most cases the child’s breasts will go back to normal when they are no longer exposed to Evamist®.
- Talk to your healthcare provider about the correct use of Evamist® when around children
- Talk to your healthcare provider to discuss other treatments for your menopause symptoms if accidental exposure to Evamist® cannot be avoided
Evamist® (estradiol transdermal spray) contains alcohol, and alcohol-based liquids are flammable. Avoid fire, flame, or smoking when using Evamist® until the spray has dried. Do not apply Evamist while standing near a flame.
Evamist® (estradiol transdermal spray) can be stored in a clean, dry place at room temperature (15° to 30°C or 59° to 86°F) and does not need refrigeration. Do not freeze.
Evamist® (estradiol transdermal spray) should not be used after the expiration date.
Helpful Resources
HOW EVAMIST WORKS
The Estrogen Spray for Hot Flashes
Patient Support
Instructional Video, Downloads & FAQs
Rx Savings
Access the Evamist® Coupon & Terms
References:
- Evamist® (estradiol transdermal spray) Prescribing Information, Padagis, October 2024.
- Data on file, Padagis.
- Nachtigall LE. Emerging delivery systems for estrogen replacement: aspects of transdermal and oral delivery. Am J Obstet Gynecol. 1995;173:993-997.
- Buster JE, Koltun WD, Pascual MLG, Day WW, Peterson C. Low-Dose Estradiol Spray to Treat Vasomotor Symptoms. Obstetrics & Gynecology. 2008;111(6):1343–1351.
