Hot Flashes

Knowing your symptoms is the first step — and it can help you and your doctor decide if Evamist^® is the right treatment for you.

Understanding Hot Flashes

Hot flashes are one of the most common symptoms of menopause.

Estrogens are hormones made by a woman’s ovaries. The ovaries normally stop making estrogen when a woman is between 45 and 55 years old, causing the “change of life,” or menopause. Sometimes both ovaries are removed during surgery before natural menopause occurs, and this sudden drop in estrogen causes “surgical menopause.”¹

When estrogen levels begin dropping, some women experience uncomfortable symptoms such as feelings of warmth in the face, neck, and chest, or sudden, intense feelings of heat and sweating. In some women, these symptoms are mild and don’t require treatment with estrogen. In other women, symptoms can be more severe.¹

Hot Flash Facts

Hot flashes, or hot flushes, are the most common of all menopause symptoms. In fact, during perimenopause, more than 75% of women in North America experience hot flashes.¹
Hot flashes can cause flushing in the face and neck, an uncomfortable feeling of warmth, sweating and chills, and even increased heart rate.²
According to the Mayo Clinic, women might experience as few as one or two hot flashes a day, or as many as one an hour. They are common at night, and each one usually lasts only a few minutes.²

The Hot Flash Experience

Hot flashes begin as a sudden warmth and flushing in the chest and face that rapidly spreads throughout the body, often accompanied by palpitations and profuse sweating, and typically concluding with chills.

Hot flashes begin with a sudden sensation of warmth and flushing in the chest and face.

Feelings of warmth and flushing rapidly generalize throughout the body.

Hot flashes may also include heart palpitations and profuse sweating.

Frequently hot flash episodes are followed by chills.

How Evamist^® Helps

Evamist^® (estradiol transdermal spray) is indicated for the treatment of moderate to severe vasomotor symptoms due to menopause. It works by delivering estradiol — an estrogen hormone — directly through the skin and into the bloodstream with a simple daily spray to the forearm.³

Proven to reduce frequency and severity

In a 12-week, randomized, placebo-controlled clinical trial of 454 postmenopausal women experiencing frequent moderate to severe hot flashes (an average of 8 or more per day), Evamist^® showed statistically significant improvement over placebo at both Week 4 and Week 12.³

FREQUENCY:

All three tested doses (1, 2, or 3 sprays daily) significantly reduced the number of daily hot flashes compared to placebo.³

SEVERITY:

All three doses also significantly reduced hot flash severity compared to placebo.³

Dosing to fit your journey

Every Evamist^® spray releases the same measured dose — 1.53 mg of estradiol. Treatment starts with one spray per day, and your healthcare provider can increase this to two or three sprays based on how you respond, without needing a new prescription.³ You and your healthcare provider should talk regularly — for example, every 3 to 6 months — about your dose and whether treatment is still right for you.

Talk to your Healthcare Provider

If hot flashes are affecting your daily life, ask your healthcare provider whether Evamist^® may be right for you. Please see full Prescribing Information, including Boxed Warning, for important safety information.

Helpful Resources

HOW EVAMIST^® WORKS

The Estrogen Spray for Hot Flashes

ABOUT EVAMIST^®

Patient Support

Instructional Video, Downloads & FAQs

BROWSE RESOURCES

Rx Savings

Access the Evamist^® Coupon & Terms

DOWNLOAD SAVINGS

References:

The North American Menopause Society. The Menopause Guidebook, Seventh Edition. 2012, pp. 9-10.
Mayo Clinic. “Diseases and Conditions: Hot flashes.” July 20, 2015. http://www.mayoclinic.org/diseases-conditions/hot-flashes/basics/definition/con-20034883
Evamist® (estradiol transdermal spray) Prescribing Information, Padagis, October 2024.

Important Safety Information for EVAMIST® (estradiol transdermal spray)

What is the most Important Information I should know about EVAMIST (an estrogen hormone)?

Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
Report any unusual vaginal bleeding right away while you are using EVAMIST. Vaginal bleeding after menopause may be a warning sign of cancer of the womb.
Do not use estrogen alone or with progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
Using estrogen-alone or with progestins may increase your chances of getting strokes, blood clots, or dementia.
Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
The estrogen in EVAMIST spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed EVAMIST. Young children who are accidentally exposed to estrogen through contact with women using EVAMIST may show signs of puberty that are not expected (for example, breast budding).
You and your healthcare provider should talk regularly about whether you still need treatment with EVAMIST.

Do not start using EVAMIST if you have unusual vaginal bleeding; have been diagnosed with a bleeding disorder; currently have or have had certain cancers; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; are allergic to EVAMIST or any of its ingredients

Before you use EVAMIST, tell your healthcare provider if you have any unusual vaginal bleeding; have any other medical conditions; are going to have surgery or will be on bed rest; are pregnant or think you may be pregnant; or are breast feeding

Tell your healthcare provider about all medicines you take. Some medicines may affect how EVAMIST works. EVAMIST may also affect how your other medicines work.

Talk to your healthcare provider about other treatments for your menopause symptoms if accidental exposure to EVAMIST cannot be avoided.

EVAMIST contains alcohol, which is flammable. Avoid fire, flame, or smoking until the area of your skin where you have applied EVAMIST has dried.

The most common side effects associated with EVAMIST are headache, breast tenderness, nipple pain, back pain and nasopharyngitis.

These are not all the possible side effects of EVAMIST. For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.

For more information about Evamist, contact Customer Service at 1-866-634-9120, Monday-Friday, 8:00 am-5:00 pm (EST).

Healthcare professionals and patients with inquiries or adverse event reports, please call 1-866-634-9120.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The information on this Web site should not take the place of talking with your doctor or healthcare professional. If you have any questions about your condition, or if you would like more information about Evamist, talk to your doctor or pharmacist. Only you and your healthcare professional can decide if Evamist^® (estradiol transdermal spray) is right for you.