Evamist - What Causes Hot Flashes
For the treatment of moderate-to-severe vasomotor symptoms due to menopause
Full Prescribing Information

If you’re experiencing night sweats, consider Evamist.

Evamist has been approved for the treatment of moderate to severe vasomotor symptoms due to menopause.

Episodes of excessive nighttime sweating are considered a type of hot flash or vasomotor symptom. They occur during sleep hours, may be strong enough to disrupt normal sleep patterns and are generally considered a moderate to severe type of hot flash.1

If you experience night sweats due to menopause, talk with your healthcare provider. He or she can recommend treatment options that may help, including Evamist® (estradiol transdermal spray).

When Evamist is applied at 8 a.m., the medicine level in your system peaks between 2 and 6 a.m., during typical sleep hours.2

Plus, a prescription for Evamist provides dosing flexibility. You may start with the lowest dose – one spray – and still have the option of applying a higher dose – two or three sprays – according to your doctor’s instruction. This helps ensure you experience the potential benefits of the medication at the lowest effective dose.

When applied at 8am, Evamist delivers peak levels of estradiol during sleep hours.

A clinical study evaluated Evamist for the treatment of moderate to severe vasomotor symptoms due to menopause in 454 women. The study demonstrated that Evamist significantly reduced how often the women experienced hot flashes, as well as the severity of the hot flashes.3

If you’re experiencing moderate to severe hot flashes, including night sweats, talk to your doctor to find out if Evamist® (estradiol transdermal spray) is right for you.

For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.


  1. Utian W. (2005) Menopause Practice: a Clinician’s Guide 2nd edition. Cleveland, OH: North American Menopause Society.
  2. Buster JE, Koltoun WD, Pascual MLG, et al. Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial. Obstet Gynecol 2008; 111:1343-51.
  3. Greene JG. Constructing a standard climacteric scale. Maturitas. 1998 May 20;29 (1):25-31.
  4. Evamist® (estradiol transdermal spray) Prescribing Information, Perrigo, January 2015.

Important Safety Information for EVAMIST (estradiol transdermal spray)

What is the most Important Information I should know about EVAMIST (an estrogen hormone)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EVAMIST. Vaginal bleeding after menopause may be a warning sign of cancer of the womb. Your healthcare provider should check any unusual vaginal bleeding to find the cause.
  • Do not use estrogen alone or with progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone or with progestins may increase your chances of getting strokes, blood clots, or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • The estrogen in EVAMIST spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed EVAMIST. Young children who are accidentally exposed to estrogen through contact with women using EVAMIST may show signs of puberty that are not expected (for example, breast budding).
  • You and your healthcare provider should talk regularly about whether you still need treatment with EVAMIST.

Do not start using EVAMIST if you have unusual vaginal bleeding; currently have or have had certain cancers; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have been diagnosed with a bleeding disorder; are allergic to EVAMIST or any of its ingredients; or think you may be pregnant

Before you use EVAMIST, tell your healthcare provider if you have any unusual vaginal bleeding; have any other medical conditions; are going to have surgery or will be on bed rest; are breast feeding

Tell your healthcare provider about all medicines you take. Some medicines may affect how EVAMIST works. EVAMIST may also affect how your other medicines work.

Talk to your healthcare provider about other treatments for your menopause symptoms if accidental exposure to EVAMIST cannot be avoided.

EVAMIST contains alcohol, which is flammable. Avoid fire, flame, or smoking until the area of your skin where you have applied EVAMIST has dried.

The most common s side effects associated with EVAMIST are headache, breast tenderness, nipple pain, back pain and nasopharyngitis.

These are not all the possible side effects of EVAMIST. For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.