Evamist - Hormone Therapy for Hot Flashes
For the treatment of moderate-to-severe vasomotor symptoms due to menopause
Full Prescribing Information

What are effective treatments for hot flashes or hot flushes?

The answers will vary, depending on whom you ask. The good news is that there are a number of treatment options available to reduce the incidence and/or severity of hot flashes.

Multiple studies have documented that prescription hormone replacement therapy (HRT) with estrogen that is systemic (circulated in the body through the bloodstream) is an effective treatment available for hot flashes. Hormone replacement therapy works by supplementing your body with the hormones that it used to make more of before menopause – specifically estradiol, which is produced by your ovaries.1

Two types of hormone replacement therapy are:

Estrogen Therapy (ET)

The decreasing amount of estrogen produced by your ovaries is what causes menopausal symptoms. Estrogen therapy is designed to add estrogen to your body during menopause, which may help reduce your symptoms. Estrogen alone is generally prescribed for women who are going through menopause and have had a hysterectomy. For more information, please refer to below section Estrogen plus progestogen therapy (EPT).

Estrogen Plus Progestogen Therapy (EPT)

Progestogen is a hormone that helps prevent the lining of the uterus from thickening, so a progestrogen is usually prescribed together with estrogen in women who have not had a hysterectomy, to protect them against uterine (endometrial) cancer.2

There are risks associated with estrogen therapy such as the possibility of blood clots, stroke, and breast cancer. An increased risk of cancer of the uterus has also been reported with the use of estrogen alone in women with a uterus.3

There are many hormone therapy options available, each with associated benefits and risks. The two most commonly used options are:

A wide range of estrogen types, delivery methods, and dosage strengths gives you the opportunity to find the best option for you.

Your doctor can help you determine which hormone replacement therapy is right for you. Before your visit, be sure you’re prepared to discuss your symptoms. To help you prepare for that discussion, download our Menopause Snapshot to help you define your symptoms and situation.


  1. Nathan L. Menopause and postmenopause. In: DeCherney AH, Nathan L, Goodwin TM, Laufer N, eds. Current Diagnosis and Treatment Obstetrics and Gynecology. 10th ed. McGraw-Hill’s AccessMedicine. Available at: www.accessmedicine.com. Accessed March 3, 2008.
  2. The North American Menopause Society. The Menopause Guidebook, Seventh Edition. 2012. pp. 10-12, 49.
  3. ACE Menopause Guidelines Revision Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocr Pract. 2006;12:315-337.

Important Safety Information for EVAMIST (estradiol transdermal spray)

What is the most Important Information I should know about EVAMIST (an estrogen hormone)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EVAMIST. Vaginal bleeding after menopause may be a warning sign of cancer of the womb. Your healthcare provider should check any unusual vaginal bleeding to find the cause.
  • Do not use estrogen alone or with progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone or with progestins may increase your chances of getting strokes, blood clots, or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • The estrogen in EVAMIST spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed EVAMIST. Young children who are accidentally exposed to estrogen through contact with women using EVAMIST may show signs of puberty that are not expected (for example, breast budding).
  • You and your healthcare provider should talk regularly about whether you still need treatment with EVAMIST.

Do not start using EVAMIST if you have unusual vaginal bleeding; currently have or have had certain cancers; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have been diagnosed with a bleeding disorder; are allergic to EVAMIST or any of its ingredients; or think you may be pregnant

Before you use EVAMIST, tell your healthcare provider if you have any unusual vaginal bleeding; have any other medical conditions; are going to have surgery or will be on bed rest; are breast feeding

Tell your healthcare provider about all medicines you take. Some medicines may affect how EVAMIST works. EVAMIST may also affect how your other medicines work.

Talk to your healthcare provider about other treatments for your menopause symptoms if accidental exposure to EVAMIST cannot be avoided.

EVAMIST contains alcohol, which is flammable. Avoid fire, flame, or smoking until the area of your skin where you have applied EVAMIST has dried.

The most common s side effects associated with EVAMIST are headache, breast tenderness, nipple pain, back pain and nasopharyngitis.

These are not all the possible side effects of EVAMIST. For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.