Evamist - All About Menopause
For the treatment of moderate-to-severe vasomotor symptoms due to menopause
Full Prescribing Information

What is menopause?

Very simply, menopause is a normal transition every woman goes through in her life, when her menstrual periods stop. It is often called the "change of life" or menopause. During this transition, a woman's body slowly makes less of the hormones estrogen and progesterone.1

The entire menopause transition is a journey through these stages:

For some women, premature menopause is part of this transition journey. This is menopause that occurs before the age of 40, whether naturally occurring or induced by medical or surgical means.1

When a woman has not had a period for 12 consecutive months, and there are no other causes for this change, she has reached menopause.1

How long does menopause last?

Most women naturally enter the beginning phase of this transition in their 40s or 50s. Research shows that 95% of women go through menopause between the ages of 45 – 55.2 The average age for menopause is 51.3

When a woman is at menopause age, she stops having her monthly period. The menopausal transition usually takes between four and five years for most women. Women who smoke typically reach menopause about one-and-a-half years earlier than non-smokers.3

Every woman experiences menopause differently. Although it can be a time of adjustment to the next chapter of life, the important thing to remember is that menopause is perfectly normal, and is now discussed more openly than ever.

There is also a wealth of information about menopause
available, especially about treatment options. You should partner with your doctor to check your health, discuss any menopause-related symptoms, and find the symptom relief that’s best for you.

Menopause Age Distribution Chart

For additional information on menopause, please consult these resources:

North American Menopause Society (NAMS)

NAMS is North America’s leading independent, nonprofit organization dedicated to promoting the health and quality of life of women through an understanding of menopause. http://www.menopause.org

American College of Obstetricians and Gynecologists (ACOG)

ACOG is a membership organization of obstetrician/gynecologists dedicated to the advancement of women’s health through education, advocacy, practice, and research.

Food and Drug Administration (FDA) Office of Women’s Health

The FDA regulates the drugs that make up different kinds of hormone replacement therapy. http://www.fda.gov/womens/healthinformation/menopause.html

Mayo Clinic

The online Women’s Health Center provides a comprehensive overview of menopause, covering symptoms, causes, risk factors, treatment options, and self-care measures. http://www.mayoclinic.com/health/menopause/DS00119

National Women’s Health Information Center (NWHIC)

NWHIC is a service of the Office on Women’s Health in the US Department of Health and Human Services. http://www.womenshealth.gov


  1. G Ellis. Understanding what happens in menopause. Philadelphia Tribune, February 24, 2015:8A.
  2. Deecher. Arch Womens Men health. 2007 10:247 - 257; UpToDate; ClearView Analysis.
  3. CDC Women’s Health Facts; Gold. SWAN Study. Am J Pub Health. 2006 96(7): 1226-1235; ClearView Analysis.

Important Safety Information for EVAMIST (estradiol transdermal spray)

What is the most Important Information I should know about EVAMIST (an estrogen hormone)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EVAMIST. Vaginal bleeding after menopause may be a warning sign of cancer of the womb. Your healthcare provider should check any unusual vaginal bleeding to find the cause.
  • Do not use estrogen alone or with progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone or with progestins may increase your chances of getting strokes, blood clots, or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • The estrogen in EVAMIST spray can transfer from the area of skin where it was sprayed to other people. Do not allow others, especially children, to come into contact with the area of your skin where you sprayed EVAMIST. Young children who are accidentally exposed to estrogen through contact with women using EVAMIST may show signs of puberty that are not expected (for example, breast budding).
  • You and your healthcare provider should talk regularly about whether you still need treatment with EVAMIST.

Do not start using EVAMIST if you have unusual vaginal bleeding; currently have or have had certain cancers; had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; have been diagnosed with a bleeding disorder; are allergic to EVAMIST or any of its ingredients; or think you may be pregnant

Before you use EVAMIST, tell your healthcare provider if you have any unusual vaginal bleeding; have any other medical conditions; are going to have surgery or will be on bed rest; are breast feeding

Tell your healthcare provider about all medicines you take. Some medicines may affect how EVAMIST works. EVAMIST may also affect how your other medicines work.

Talk to your healthcare provider about other treatments for your menopause symptoms if accidental exposure to EVAMIST cannot be avoided.

EVAMIST contains alcohol, which is flammable. Avoid fire, flame, or smoking until the area of your skin where you have applied EVAMIST has dried.

The most common s side effects associated with EVAMIST are headache, breast tenderness, nipple pain, back pain and nasopharyngitis.

These are not all the possible side effects of EVAMIST. For more information, refer to the Patient Information section of the full Prescribing Information or ask your healthcare provider or pharmacist.